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Synthesis of 1‐triphenylgermylpropiono‐4‐substituted semicarbazides, thiosemicarbazides and their heterocyclic derivatives
Author(s) -
Ruyu Chen,
Fengfu Li
Publication year - 1995
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590090311
Subject(s) - chemistry , chloroform , sodium hydroxide , nuclear chemistry , elemental analysis , proton nmr , medicinal chemistry , hydroxide , inorganic chemistry , stereochemistry , organic chemistry
Abstract Twenty‐one new organogermanium compounds with the formulae Ph 3 GeCHR 1 CH 2 CONHNHC(X)NHR 2 (1) (R 1 =H, Ph; = Ph, p ‐CH 3 Ph, O ‐CH 3 Ph, p ‐ClPh, COPh, X = S, O) and(R 1 = H, Ph; R 2 = Ph, p ‐CH 3 Ph, o ‐CH 3 Ph, p ‐ClPh; X=S, O) were synthesized and characterized by elemental analysis, 1 H NMR, IR, MS and X‐ray diffraction techniques. Compounds l were prepared by the reactions of Ph 3 GeCHR 1 CH 2 CONHNH 2 with R 2 NCX in chloroform in 77‐94% yields, and 2 were obtained by refluxing l with sodium hydroxide (8%) with yields of 55‐94%.