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Stereochemical and biochemical aspects of organoboron(III) compounds of hydrazonecarboxamides and hydrazonecarbothioamides
Author(s) -
Saxena Chitra,
Singh R. V.
Publication year - 1995
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590090310
Subject(s) - chemistry , hydrazine (antidepressant) , antifungal , nuclear magnetic resonance spectroscopy , organic chemistry , biochemistry , microbiology and biotechnology , biology
Hydrazonecarboxamides and hydrazonecarbothioamides and their derivatives have important pharmacodynamic significance. In the search for better fungicides and bactericides, organoboron(III) compounds derived from these ligands were screened for their antifungal and antibacterial activities. The heterocyclic aldimines were prepared by the condensation of (2‐furanyl)methanal, (2‐thienyl)methanal, (2‐pyridinyl)methanal, (1 H ‐indol‐3‐yl)methanal or 3‐phenyl‐2‐propenal with hydrazinecarboxamide or hydrazine‐carbothioamide. Unimolar and bimolar reactions between phenyldihydroxyborane and these ligands have produced PhB(OH)(NO), PhB(NO) 2 , PhB(OH)(NS) and PhB(NS) 2 types of biologically active compounds. Structural assignment has been made through UV, IR and NMR ( 1 H, 11 B and 13 C) spectroscopy. TGA and XRD of a representative compounds have also been carried out. The compounds were tested in vitro against a number of fungal and bacterial strains and were found to possess moderate to good toxicity.