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Di(n‐butyl)tin bis(dihydroxybenzoate)s: Synthesis, spectroscopic characterization and in vitro antitumour activity
Author(s) -
Gielen Marcel,
Bouhdid Abdeslam,
Kayser Françcois,
Biesemans Monique,
Willem Rudolph,
De Vos Dick,
Mahieu Bernard
Publication year - 1995
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590090308
Subject(s) - tin , chemistry , in vitro , stereochemistry , cisplatin , nuclear magnetic resonance spectroscopy , mössbauer spectroscopy , cell culture , nuclear chemistry , biochemistry , organic chemistry , crystallography , chemotherapy , medicine , surgery , biology , genetics
Six di(n‐butyl)tin(IV) and two dimethyltin(IV) bis‐(dihydroxybenzoate)s were synthesized and characterized by 1 H, 13 C and 119 Sn NMR and Mössbauer spectroscopy. Five of the di(n‐butyl)tin compounds were screened in vitro against six human tumour cell lines, MCF‐7, EVSA‐T, WiDr, IGROV, M19 and A498. They are more active than carboplatin, cisplatin and 5‐fluorouracil against all cell lines and of comparable activity or better than methotrexate. All dihydroxybenzoates with an ortho ‐bydroxyl group are more active against MCF‐7 cells than substituted salicylates screened previously.