Premium
Organotin(IV) complexes with tetraethyl ethylene‐ and propylene‐diphosphonates
Author(s) -
Grigoriev E. V.,
Yashi. S.,
Prischenko A. A.,
Livantsov M. V.,
Petrosyan V. S.,
Massa W.,
Harms K.,
Wocadlo S.,
Pellerito L.
Publication year - 1995
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590090104
Subject(s) - chemistry , diphosphonates , ethylene , medicinal chemistry , organic chemistry , catalysis , genetics , bone resorption , biology
The series of organotin halide complexes with tetraethyl ethylene‐ and propylene‐diphosphonates R n SnX 4– n ,˙L [ n =0, X=Cl; n =1, R=Me, X=Cl, Br; n =1, R=Ph, X=Cl; n =2, R=Me, Et, Bu, X=Cl, Br; n =2, R=Ph, X=Cl; L=(EtO) 2 P(O)CH 2 CHR'P(O)(OEt) 2 , R'=H, Me] were synthesized and characterized by means of NMR and Mössbauer spectroscopy. The crystal structure of the complex of diphenyltin dichloride with propylenediphosphonate was determined. The complex consists of polymer chains with bridging bidentate ligands and an octahedral tin environment containing two types of phosphoryl fragments. All of the R 2 SnX 2 adducts have trans ‐R 2 SnX 4 geometries of tin coordination octahedra according to the quadrupole splitting values in the Mössbauer spectra. The 31 P and 119 Sn NMR studies at low temperatures revealed that RSnHal 3 complexes in solution form isomers with different mutual orientations of phosphoryl ligands and organic groups in the coordination sphere. The diethyltin dichloride adduct with ethylene‐diphosphonate appeared to be active against lung cancer NCI‐H522 cells.