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Synthesis and radiopharmacological study of new metallated thiazolidines and dithioacetals of N ‐allyl‐substituted cysteamine and methylcysteamine
Author(s) -
Rima G.,
Satge J.,
SentenacRoumanou H.,
Fatome M.,
Laval J. D.,
Lion C.,
Alazard O.,
Chabertier P.
Publication year - 1994
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590080508
Subject(s) - cysteamine , chemistry , toxicity , stereochemistry , semicarbazone , organic chemistry
New germa‐ and silathiazolidines or germa‐ and siladithioacetals with N ‐allyl‐substituted cysteamine and methylcysteamine ligands have been synthesized and their pharmacological properties (toxicity, radioprotective activity) have been studied. A notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new organometallic derivatives compared to N ‐allyl‐substituted cysteamine and methylcysteamine were observed.