Synthesis and radiopharmacological study of new metallated thiazolidines and dithioacetals of  N ‐allyl‐substituted cysteamine and methylcysteamine | Zendy

Rima G. | Zendy; Satge J. | Zendy; SentenacRoumanou H. | Zendy; Fatome M. | Zendy; Laval J. D. | Zendy; Lion C. | Zendy; Alazard O. | Zendy; Chabertier P. | Zendy

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Synthesis and radiopharmacological study of new metallated thiazolidines and dithioacetals of N ‐allyl‐substituted cysteamine and methylcysteamine

Author(s) -

Rima G.,

Satge J.,

SentenacRoumanou H.,

Fatome M.,

Laval J. D.,

Lion C.,

Alazard O.,

Chabertier P.

Publication year - 1994

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.590080508

Subject(s) - cysteamine , chemistry , toxicity , stereochemistry , semicarbazone , organic chemistry

New germa‐ and silathiazolidines or germa‐ and siladithioacetals with N ‐allyl‐substituted cysteamine and methylcysteamine ligands have been synthesized and their pharmacological properties (toxicity, radioprotective activity) have been studied. A notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new organometallic derivatives compared to N ‐allyl‐substituted cysteamine and methylcysteamine were observed.

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