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Pulmonary toxicity of indium arsenide and arsenic selenide following repeated intratracheal instillations to the lungs of hamsters
Author(s) -
Tanaka Akiyo,
Hisanaga Akira,
Hirata Miyuki,
Omura Minoru,
Inoue Naohide,
Ishinishi Noburu
Publication year - 1994
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590080318
Subject(s) - lung , selenide , carcinogen , intratracheal instillation , toxicity , chemistry , arsenic , adenocarcinoma , hamster , lung tumor , medicine , endocrinology , physiology , gastroenterology , andrology , cancer , selenium , biochemistry , organic chemistry , bronchoalveolar lavage
Chronic toxicity of indium arsenide (InAs) and arsenic selenide (As 2 Se 3 ) was studied in male Syrian golden hamsters which received InAs or As 2 Se 3 particles, each containing a total dose of 7.5 mg of arsenic, by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total lifespan, the cumulative body weight gain of the hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the As 2 Se 3 group when compared with that in the control group. However, the survival rate for the InAs group was significantly higher compared with the control group, but not for the As 2 Se 3 group when compared with the control group. During the animals' total lifespan, one lung adenoma was seen in the 27 hamsters in the InAs group and one lung adenoma in the 23 hamsters in the control group. No tumors of the lung were observed in the As 2 Se 3 group. Malignant tumors outside the lung appeared in four hamsters in the InAs group and in two in the As 2 Se 3 group. No non‐lung malignant tumours were seen in the control group. Total tumor incidence rates were 25.9% (7/27) in the InAs group, 10.3% (3/29) in the As 2 Se 3 group and 8.7% (2/23) in the control group. There were therefore no significant differences in tumor incidence between the InAs or the As 2 Se 3 group, and the control group. Regarding histopathological findings in the lung, incidence rates of proteinosis‐like lesions, pneumonia, metaplastic ossification and emphysema were seen only in the InAs group, and alveolar or bronchiolar cell hyperplasia observed in both the InAs and the As 2 Se 3 groups were at significantly higher rates than those in the control group. From these results, it was concluded that InAs and As 2 Se 3 particles could induce pulmonary toxicity when instilled intratracheally into hamsters. A great deal of attention should be paid to the toxicity of both InAs and As 2 Se 3 , even though in this study the adverse health effects of As 2 Se 3 appeared to be less than those of InAs.