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Enhancing effects of an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in a multi‐organ carcinogenesis bioassay
Author(s) -
Yamamoto Shinji,
Konishi Yoshitsugu,
Murai Takashi,
Shibata MasaAki,
Matsuda Tsutomu,
Kuroda Koichi,
Endo Ginji,
Fukushima Shoji
Publication year - 1994
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590080307
Subject(s) - chemistry , nitrosamine , carcinogen , arsenic , bioassay , urine , thyroid , urinary system , carcinogenesis , kidney , pharmacology , medicine , biochemistry , organic chemistry , biology , gene , genetics
The modifying effects of dimethylarsinic acid (DMA) on tumor induction in various organs were examined using a multi‐organ rat carcinogenesis bioassay. A total of 124 six‐week‐old male F344/DuCrj rats were divided randomly into seven groups. For establishment of wide‐spectrum initiation, animals in Groups 1–5 were treated with five carcinogens, namely N ‐nitrosodiethylamine (DEN), N ‐methyl‐ N ‐nitrosourea (MNU), 1,2‐dimethylhydrazine (DMH), N ‐butyl‐ N ‐(4‐hydroxybutyl)nitrosamine (BBN) and N ‐bis(2‐hydroxypropyl)nitrosamine (DHPN) in the first four weeks. After a two‐week interval, Groups 1–5 were then given 0, 50, 100, 200 and 400 ppm DMA, respectively, in drinking water. Groups 6 and 7 received 100 and 400 ppm DMA without any carcinogen pretreatment. All rats were sacrificed at the end of week 30. In the initiated groups (Groups 1–5), DMA enhanced tumor development in the urinary bladder, kidney, liver and thyroid gland. The main arsenic species in urine samples was DMA itself. In conclusion, the observed enhancement of carcinogenesis in the urinary tract as well as in the liver and thyroid gland may be directly due to this arsenic compound.