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Metal–Nitrosyl complexes as a source of new vasodilators: Strategies derived from systematic chemistry and nitrosyl ligand reactivity
Author(s) -
Reglinski J.,
Butler A. R.,
Glidewell C.
Publication year - 1994
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590080106
Subject(s) - chemistry , reactivity (psychology) , nucleophile , ligand (biochemistry) , metal , sodium nitroprusside , medicinal chemistry , stereochemistry , organic chemistry , nitric oxide , catalysis , medicine , biochemistry , alternative medicine , receptor , pathology
A series of nitrosyl complexes of empirical formula K n [M(CN) 5 NO], where M = V, Cr, Mn and Co and n = 3, or M = Mo and n = 4, have been prepared which are notional analogues of the widely used vasodilator sodium nitroprusside. Their reactivity towards common nucleophiles (OH − , NH 2 R, NHR 2 , HS − and RS − ), acid and photolysis has been investigated to elucidate the desired properties required of new metal nitrosyls which may have some potential as new non‐cyanide‐based vasodilators.