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Crystal structure and in vitro antitumour activity of dibutylbis(5‐chloro‐2‐hydroxybenzoato)tin(IV)
Author(s) -
Gielen Marcel,
Bouâclam Mohammed,
Mahieu Bernard,
Tiekink Edward R. T.
Publication year - 1994
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590080105
Subject(s) - chemistry , tin , carboxylate , crystal structure , bipyramid , crystallography , stereochemistry , hydrogen bond , trigonal bipyramidal molecular geometry , atom (system on chip) , chelation , monomer , in vitro , pentagonal bipyramidal molecular geometry , basal plane , molecule , inorganic chemistry , organic chemistry , embedded system , polymer , biochemistry , computer science
The crystal structure of the title compound, [nBu 2 Sn(5‐Cl‐2‐OH‐C 6 H 3 CO 2 ) 2 ], shows that in the monomeric species the six‐coordinate Sn atom exists in a skew trapezoidal bipyramidal geometry in which the four O donor atoms, derived from two asymmetrically chelating carboxylate ligands, define the basal plane and the n‐butyl substituents lie over the weaker SnO interactions defining a CSnC angle of 147.6(2)°. An unusual feature of the structure is the presence of both intra‐ and inter‐molecular hydrogen bonding contacts which serve to stabilize the structure. The in vitro antitumour activity of this compound against mammary and colon carcinoma cell lines is also reported.