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Antimicorbial effects of newly synthesized organotin(IV) and organolead(IV) derivatives
Author(s) -
Kumari Anita,
Tandon J P,
Singh R V
Publication year - 1993
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590070809
Subject(s) - chemistry , chloride , ligand (biochemistry) , antimicrobial , elemental analysis , medicinal chemistry , organic chemistry , biochemistry , receptor
Triorganotin(IV) and triorganolead(IV) derivatives of the types Me 3 Sn(SCZ) and Ph 3 Pb(SCZ) (where SCZ − is the anion of a semicarbanzone ligand) have been synthesized by substitution reactions of trimethyltin chloride and triphenyl‐lead chloride with semicarbazones derived from heterocyclic ketones. The resulting complexes have been characterized by elemental analyses, molecualr weight determinations and conductivity measurements. The mode of bonding has been established on the basis of infrared and 1 H, 13 C and 119 Sn NMR spectroscopic studies. Some respresentative complexes have also been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria; the results of these investigations have been reported in the present paper.