Premium
Diorganotin(IV) dipeptide complexes with potential antitumour activity
Author(s) -
Guli G,
Gennaro G,
Pellerito L,
Stocco G C
Publication year - 1993
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590070608
Subject(s) - chemistry , stereochemistry , imidazole , trigonal bipyramidal molecular geometry , dipeptide , carboxylate , thioether , histidine , deprotonation , moiety , monomer , mössbauer spectroscopy , nuclear magnetic resonance spectroscopy , peptide , crystallography , amino acid , crystal structure , organic chemistry , biochemistry , ion , polymer
A series of complexes of the dimethylltin(IV) moiety with dipeptides has been synthesized. The dipeptides are L ‐alanyl‐ L ‐histidine (H 2 AlaHis), L ‐methionyl‐ L ‐methionine (H 2 MetMet), L ‐glycyl‐ L ‐histidine (H 2 GlyHis) and L ‐histidyl‐ L ‐glycine (H 2 HisGly). The complexes have been characterized by IR and 119 Sn Mössbauer spectroscopy in the solid state and by 1 H NMR in CD 3 OD and D 2 O solutions. They consist of monomeric entities, with the tin atom arranged in a pentacoordinated trigonal bipyramidal structure. The dipeptides are coordinated via the amino group, deprotonated peptide nitrogen and carboxylate group. Neither imidazole in histidine‐containing dipetides, nor the thioether group in MetMet, is involved in bonding; they act as pendant arms on the outer surface of the complexes.