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Antifertility and biocidal activities of organometallics of silicon, germanium, titanium and zirconium derived from 2‐acetylthiophene thiosemicarbazone
Author(s) -
Singh Devendra,
Kumari Anita,
Singh R V,
Mehta S M,
Gupta I J,
Singh K
Publication year - 1993
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590070408
Subject(s) - organosilicon , chemistry , semicarbazone , zirconium , titanium , germanium , nuclear chemistry , silicon , proton nmr , molecule , carbon 13 nmr , organic chemistry , medicinal chemistry , stereochemistry
A comparative biochemical study of four Group IV element compounds with specific sulphur‐containing organic substrates has been carried out and discussed. The structural characterizations of these organometallics, viz. Me 2 SiLCl, Me 2 SiL 2 , Me 3 SiL, Ph 2 SiLCl, Ph 2 SiL 2 , Ph 3 SiL, Ph 3 GeL, Cp 2 TiLCl, Cp 2 TiL 2 , Cp 2 ZrLCl and Cp 2 ZrL 2 (where LH2‐acetylthiophene thiosemicarbazone) had been deduced on the basis of various physico‐chemical and instrumental techniques, viz., IR, UV, 1 H NMR, 13 C NMR AND 29 SI NMR spectral studies. All the organometallics and the parent thiomine have been screened against a number of microbes and their sterilizing power in male mice tested. The results of these biocidal studies show that the organosilicon(IV) and organogermanium(IV) compounds are more active than the organotitanium(IV) and organozirconium(IV) derivatives. An attempt has also been made to correlate the structural aspects of the molecule with its biological activity.