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Diorganotin 2‐fluorocinnamates and 4‐fluorophenylacetates: Synthesis, characterization and in vitro antitumour activity
Author(s) -
Gielen Marcel,
Khloufi Abdelaziz El,
Biesemans Monique,
Kayser François,
Willem Rudolph
Publication year - 1993
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590070307
Subject(s) - chemistry , in vitro , cisplatin , cell culture , stereochemistry , microbiology and biotechnology , cancer research , biochemistry , medicine , chemotherapy , biology , genetics
Abstract The synthesis and characterization by spectroscopy of several new di‐n‐butyltin and diethyltin 2‐fluorocinnamates and 4‐fluorophenylacetates are described. In vitro tests on two human tumour cell lines, MCF‐7, a mammary tumour, and WiDr, a colon carcinoma, showed that two of these compounds are more active than cisplatin. Other in vitro tests performed by the NCI, USA on a panel of human tumour cell line show that one of them, bis[di‐n‐butyl(2‐fluorophenylacetato)tin] oxide, is characterized by statistically significant D GI 50, D TGI and D LC 50sensitivities, but non‐significant D H and MGD H selectivities, whereas the analogous 2‐fluorocinnamate shows no such significant values.