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Antitumor effects of binuclear ferrocene derivatives
Author(s) -
Popova L V,
Babin V N,
Belousov Yu A,
Nekrasov Yu S,
Snegireva A E,
Borodi P,
Shaposhnikova G M,
Bychenko O B,
Raevskii P M,
Morozova N B,
Iiyina A I,
Shitkov K G
Publication year - 1993
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590070203
Subject(s) - tetrafluoroborate , chemistry , ferrocene , iodide , in vivo , stereochemistry , triiodide , biochemistry , organic chemistry , ionic liquid , microbiology and biotechnology , electrode , dye sensitized solar cell , electrolyte , electrochemistry , biology , catalysis
Abstract On the basis of an earlier model of chemical carcinogenesis, the antitumor activity of the mono‐, bi‐ and poly‐nuclear ferrocene derivatives ferricenium tri‐iodide (1), ferricenium tetrachloroferrate (2), 1, 1′‐diethylferricenium triiodide: (3), N ‐(ferrocenylmethyl)hexamethylenetetramine tetrafluoroborate (4), bis(ferrocenylmethyl)benzotriazolium tetrafluoroborate (5), bis(ferrocenyl‐α‐ethyl)benzotriazolium tetrafluoroborate (6) and bis(ferrocenylmethyl)‐2‐methylbenzimidazolium tetrafluoroborate (7), and the oligomer (—Fc—CH 2 —Fc +˙ —CH 2 —) 7–8 − (PF 6 ) 7–8 (8) was studied in vivo (FcC 10 H 8 Fe). The tumor models studied included MCH‐11 (mouse sarcoma induced by methylcholantrene), P‐815 (mouse mastocytoma of DBA/2 origin) and virus‐induced Raucher leukemia (RLV). The cytotoxic effects of these preparations were examined against in vitro cultured normal murine cells (line L‐929). The binuclear ferrocene derivatives 5, 6 and 7 inhibited the development of experimental tumors in mice. Ferricenium tri‐iodide (1) was effective in Rauscher leukemia. Kinetic dependencies for most complexes had a two‐phase character: the region of inhibition of tumorogenesis was followed by a region in which the complexes accelerated the development of this process. The link between the structure of compounds 1–8 and their antitumor effects is discussed.