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Arsenic distribution in rats fed a Hijiki diet
Author(s) -
Katayama Masayuki,
SugawaKatayama Yohko,
Tamura Tomoko
Publication year - 1992
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590060413
Subject(s) - chemistry , sodium arsenate , arsenic , arsenate , body weight , stomach , neutron activation analysis , sodium , endocrinology , medicine , zoology , biochemistry , radiochemistry , biology , organic chemistry
Very large doses of sodium arsenate (Na 2 HAsO 4 ), 14 mg As kg −1 of body weight, were administered to Sprague‐Dawley male rats (body weight 300 g) fed a 5% Hijiki diet by stomach tube twice within two days. After 24 h, the rats were sacrificed and various organs were dried for subsequent neutron activation analysis. The distribution of arsenic (As) in selected organs was determined by neutron activation analysis. The highest concentration of As was found in blood cells with a rather high concentration in the liver and heart. As the control, rats which were fed on a 5% cellulose diet were used. Control rats which were administered arsenate showed that the arsenic distribution and the concentration in their organs were similar to those on the 5% Hijiki diet. Even the blood cells of the controls without any arsenic administration were found to contain a small amount of arsenic.