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Exceptionally high in vitro antitumor activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor, MCF‐7, and a colon carcinoma, WiDr
Author(s) -
Gielen M,
Willem R,
Biesemans M,
Bouǎlam M,
Khloufi A El,
de Vos D
Publication year - 1992
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590060307
Subject(s) - benzoates , chemistry , in vitro , mitomycin c , stereochemistry , cancer research , medicinal chemistry , biochemistry , organic chemistry , biology , genetics
Nine new substituted triphenyltin benzoates of the type Ar 3 SnOOCC 6 H 2 XYZ [X = Y = H, Z = 2‐OCH 3 and 4‐F; X = H, Y = 3‐F, Z = 5‐F; X = H, Y = 2‐OH, Z = 5‐Cl, 5‐NH 2 , 5‐OCH 3 and 5‐SO 3 H; X = 2‐OH, Y = 3‐CH(CH 3 ) 2 and Z = 5‐CH(CH 3 ) 2 ] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF‐7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C.