Exceptionally high  in vitro  antitumor activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor, MCF‐7, and a colon carcinoma, WiDr | Zendy

Gielen M | Zendy; Willem R | Zendy; Biesemans M | Zendy; Bouǎlam M | Zendy; Khloufi A El | Zendy; de Vos D | Zendy

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Exceptionally high in vitro antitumor activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor, MCF‐7, and a colon carcinoma, WiDr

Author(s) -

Gielen M,

Willem R,

Biesemans M,

Bouǎlam M,

Khloufi A El,

de Vos D

Publication year - 1992

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.590060307

Subject(s) - benzoates , chemistry , in vitro , mitomycin c , stereochemistry , cancer research , medicinal chemistry , biochemistry , organic chemistry , biology , genetics

Nine new substituted triphenyltin benzoates of the type Ar 3 SnOOCC 6 H 2 XYZ [X = Y = H, Z = 2‐OCH 3 and 4‐F; X = H, Y = 3‐F, Z = 5‐F; X = H, Y = 2‐OH, Z = 5‐Cl, 5‐NH 2 , 5‐OCH 3 and 5‐SO 3 H; X = 2‐OH, Y = 3‐CH(CH 3 ) 2 and Z = 5‐CH(CH 3 ) 2 ] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF‐7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C.

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