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The use of liposomes in predicting the biological mobility of arsenic compounds
Author(s) -
Cullen William R,
Nelson John
Publication year - 1992
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590060211
Subject(s) - chemistry , arsenic , liposome , efflux , partition coefficient , octanol , membrane permeability , membrane , chromatography , organic chemistry , biochemistry
Efflux studies of radio‐labelled methylarsonic acid (MMA) and dimethylarsinic acid (DMA) encapsulated in liposomes afford the following permeability values for the two arsenicals: 1.4 × 10 −13 cm s −1 and 4.5 × 10 −11 cm s −1 for MMA and DMA, respectively. These data are compared with the octanol/water partition coefficients which are 7.4 × 10 −3 and 8.4 × 10 −3 for MMA and DMA, respectively.
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