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Synthesis, characterization and in vitro antitumor activity of dimethyl‐, diethyl, and di‐t‐butyl‐tin(IV) derivatives of substituted salicylic acids
Author(s) -
Bouâlam Mohammed,
Willem Rudolph,
Biesemans Monique,
Gielen Marcel
Publication year - 1991
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590050607
Subject(s) - chemistry , tin , stereochemistry , medicinal chemistry , salicylic acid , mass spectrometry , nuclear magnetic resonance spectroscopy , in vitro , organic chemistry , biochemistry , chromatography
The synthesis of dimethyl‐, diethyl‐ and/or di‐t‐butyl‐tin(IV) derivatives of substituted salicylic acids of the type a, (X‐Y‐2‐OH‐C 6 H 2 COO) 2 SnR 2 (X, Y H, H; H, 5‐CH 3 ; H, 5‐Cl; H, 5‐F; H, 3‐CH 3 O; H, 5‐CH 3 O; 3‐CH 3 , 6‐(CH 3 ) 2 CH; 3,5‐[(CH 3 ) 2 CH] 2 and 4,5‐benzo) and b {[R 2 (X‐Y‐2‐OH‐C 6 H 2 COO)Sn] 2 O} 2 (X, Y H, 3‐CH 3 O; H, 5‐CH 3 O: 3‐CH 3 , 6‐(CH 3 ) 2 CH; 3,5‐[(CH 3 ) 2 CH] 2 and 4,5‐benzo) is reported. Their characterization by 1 H, 13 C and 119 Sn NMR, Mössbauer and mass spectrometry is described. The in vitro antitumor activity of selected derivatives against two human tumoral cell lines, MCF‐7 and WiDr, is presented.