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Structural effects on the antitumour activity of organotin compounds 2. Further diaryltin dichloride complexes with nitrogen‐donor ligands
Author(s) -
Biddle Brian N,
Gray J S
Publication year - 1991
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590050512
Subject(s) - chemistry , benzimidazole , ligand (biochemistry) , stereochemistry , medicinal chemistry , nitrogen , biological activity , organic chemistry , receptor , in vitro , biochemistry
The synthesis and investigation of the anti‐tumour activity of a further series of six new diorganotin dichloride complexes Ar 2 SnCl 2 .L 2 , where Ar = 2‐thienyl, 2,4‐dimethoxyphenyl, 4‐methyoxyphenyl, 4‐methylphenyl or 4‐trifluoromethylphenyl and L 2 = 2‐(2‐pyridyl)benzimidazole (PBI) or 2‐amino‐methylpyridine (AMP), is reported. One of these complexes was found to be active against P388 lymphocytic leukaemia in mice. The results obtained are in general agreement with previously published work. The activity of the diaryltin dichloride complexes is shown to be dependent on the electronic effect of the aromatic group. The use of PBI as a ligand, however, shows no advantage over other ligands used in the series investigated.