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Evaluation of the genotoxic potential of six triorganotin compounds by the mouse micronucleus and spermhead abnormality tests
Author(s) -
Kook Sam Choon,
Kwong Ng Meng,
Das V G Kumar
Publication year - 1991
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590050507
Subject(s) - chemistry , micronucleus , micronucleus test , somatic cell , microbiology and biotechnology , stereochemistry , medicinal chemistry , biochemistry , toxicity , organic chemistry , biology , gene
Six triorganotin compounds—Ph 3 SnOH, BuPh 2 SnOH, ( p ‐CIC 6 H 4 )Ph 2 SnOH, (cyclo‐C 5 H 9 )Ph 2 SnOH, Ph 3 SnO 2 CCH 2 CS 2 NMe 2 and Bu 3 SnOSO 2 Et—were tested for their mutagenic potential in somatic and germinal cells in ICR mice by using the micronucleus and spermhead abnormality assays, respectively. In somatic cells, the compunds significantly induced chromosomal disorders at half their respective estimated LD 50 (i.p.) values (5.00–6.25 mg kg −1 body wt), and one compound, Ph 3 SnOH, even at 1/20 of its estimated LD 50 value. In germinal cells, five compounds significantly induced chromosomal disorders at 1/64 of their respective estimated LD 50 (i.p.) values, whereas one, ( p ‐CIC 6 H 4 )Ph 2 SnOH, caused such disorders only at 1/8 of its estimated LD 50 value.