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Synthesis, characterization and in vitro antitumour properties of complexes of bis(alkoxycarbonylmethyl)tin dibromides with bidentate nitrogen ligands
Author(s) -
Zhang Zhengquan,
Pan Huade,
Hu Chun,
Fu Fangxin,
Sun Yunhong,
Willem Rudolph,
Gielent Marcel
Publication year - 1991
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590050307
Subject(s) - chemistry , denticity , tin , in vitro , phenanthroline , nitrogen , characterization (materials science) , stereochemistry , proton nmr , metal , organic chemistry , biochemistry , nanotechnology , materials science
The synthesis and characterization of 10 new bis(;alkoxycarbonylmethyl)tin dibromides and of 14 of their complexes with bidentate nitrogen ligands (;bipyridyl, 1,10‐phenanthroline and 5‐nitro‐1, 10‐phenanthroline) are described. Their proton NMR spectra are discussed. Their in vitro antitumour activity against two human cancer cell lines, MCF‐7 and WiDr, is low compared to antitumour drugs used clinically.