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Antifungicidal, antibacterial and antifertility activities of biologically active heterocyclic thiosemicarbazones and their coordination complexes with the dimethylsilicon moiety
Author(s) -
Singh D,
Singh R V,
Goyal R B
Publication year - 1991
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590050106
Subject(s) - chemistry , organosilicon , moiety , trigonal bipyramidal molecular geometry , stereochemistry , octahedron , biological activity , antibacterial activity , coordination complex , bacteria , combinatorial chemistry , molecule , medicinal chemistry , organic chemistry , crystal structure , biochemistry , metal , in vitro , biology , genetics
Synthetic, structural and biological aspects of trigonal‐bipyramidal, Me 2 Si(NS)Cl and octahedral, Me 2 Si(NS) 2 types of organosilicon (IV) complexes of heterocyclic thiosemicarbazones (NSH) have been described. The complexes were characterized by elemental analysis, molecular weight determination, conductance measurements and electronic, infrared, 1 H and 13 C NMR spectral studies. Some ligands and their corresponding dimethylsilicon (IV) complexes have been tested for their effects on several pathogenic fungi and bacteria. Two representative complexes have also been found to act as sterilizing agents by reducing the production of sperm in male mice.