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The synergistic effect of polysorbate 80 upon the toxicity of tri‐n‐butyltin chloride
Author(s) -
Sherman Larry R,
Kellner Ginny L
Publication year - 1990
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590040411
Subject(s) - chemistry , toxicity , polysorbate , emulsion , polyvinyl alcohol , chloride , polyvinyl chloride , acute toxicity , chromatography , nuclear chemistry , organic chemistry , biochemistry , pulmonary surfactant
Abstract Polysorbate 80 (Tween 80) was used as an emulsifying agent for administering tri‐n‐butyltin chloride (TBTCl) to rats below, at and above the LD 50 for the compound. Tween 80 greatly enhanced the toxicity of the organotin compound. The LD 50 in the presence of Tween 80 (16% of the emulsion) is less than half of the LD 50 when the TBTCl was administered in corn oil.