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Synthesis, characterization and in vitro antitumour activity of a series of substituted 2,2‐di‐n‐butyl‐4‐oxo‐benzo‐1,3,2‐dioxastannins
Author(s) -
Bouǎlam Mohammed,
Willem Rudolph,
Gelan Jan,
Sebald Angelika,
Lelieveld Peter,
de Vos Dick,
Gielen Marcel
Publication year - 1990
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590040406
Subject(s) - chemistry , stereochemistry , mass spectrometry , nuclear magnetic resonance spectroscopy , magic angle spinning , carbon 13 nmr , medicinal chemistry , chromatography
The characterization by 1D and/or 2D 1 H NMR, 13 C NMR, 119 Sn NMR, Mössbauer and mass spectrometry of a series of di‐n‐butyltin derivatives of 3‐, 4‐, and 5‐methyl‐, 3‐, 4‐, and 5‐methoxy‐, 4‐ and 5‐amino‐substituted, and 3,5‐diiodo‐salicyclic acids is described. Their NMR spectra suggest that they are present as dimers in CDCl 3 solution, like the di‐n‐butyltin derivative of unsubstituted salicyclic acid. This has been confirmed by the observation of mixed dimers. The insoluble derivatives have been characterizerd by solid state cross polarization/magic angle spinning (CP/MAS) 13 C and/or 119 Sn NMR, Mössbauer and mass spectroscopy. These compounds are characterized in vitro by a lower inhibition dose than cis ‐platin or etoposide against a series of five human cell lines.