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Metabolism in mice of arsenic compounds contained in the red alga Porphyra yezoensis
Author(s) -
Shiomi Kazuo,
Chino Makoto,
Kikuchi Takeaki
Publication year - 1990
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590040317
Subject(s) - urine , arsenic , chemistry , arsenobetaine , chromatography , feces , metabolite , biochemistry , inorganic arsenic , microbiology and biotechnology , biology , organic chemistry
Arsenic compounds in the red alga Porphyra yezoensis were purified by gel filtration on Bio‐Gel P‐2; chromatographic behavior suggested that they were arsenic‐containing ribofuranosides (arsenosugars). When partially purified arsenosugars were orally administered to mice, 86% and 13% of the arsenic administered were excreted in feces and urine, respectively, within 48 h. Arsenic compounds excreted in feces were identified as arsenosugars by gel filtration and highperformance liquid chromatography, while those excreted in urine were identified as methylarsonic acid, dimethylarsinic acid and arsenobetaine. On the other hand, upon intravenous administration of arsenosugars, a large part of the arsenic administered was excreted rapidly in urine; after 72 h, 92% of the arsenic administered was recovered in urine and 6% in feces. Similarly to the case of oral administration, methylarsonic acid, dimethylarsinic acid and arsenobetaine were detected in urine.