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Comparative study on the tumorigenicity in mice of gallium arsenide, gallium phosphide and gallium oxide following subcutaneous and intraperitoneal injections
Author(s) -
Tanaka Akiyo,
Hisanaga Akira,
Hirata Miyuki,
Ishinishi Noburu
Publication year - 1990
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590040309
Subject(s) - intraperitoneal injection , gallium phosphide , subcutaneous injection , gallium , chemistry , gallium arsenide , medicine , materials science , optoelectronics , organic chemistry
Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs), gallium phosphide (GaP) and gallium oxide (Ga 2 O 3 ) was studied in male ICR mice which received either a subcutaneous or an intraperitoneal injection of each material once only. The doses received either subcutaneously or intraperitoneally were 48 mg Kg −1 as Ga or 480 mg Kg −1 as Ga of each material suspended in 0.2 cm 3 of olive oil. The control groups received the vehicle only, either subcutaneously or intraperitoneally. In the study using subcutaneous injections, no tumors were observed in the subcutis at the site of injection, and there was no significant difference concerning the survival periods of each group compared with the control group at the termination of the observation period. In the study using intraperitoneal injections, the total tumor incidence in all the experimental groups, except for the GaAs (480 mg Ga Kg −1 ) groups, was significantly different compared with the control group. However, all these tumors appeared to be spontaneous, rather than induced by the materials themselves. Moreover, in the GaAs (480 mg Ga Kg −1 ) and Ga 2 O 3 (48 mg Ga Kg −1 ) groups, the number of survival days was significantly lower compared with the control group. From this study, it seems that neither GaAs, GaP nor Ga 2 O 3 were tumorigenic to mice when injected subcutaneously. Although it remains unclear whether the increased production of total tumors in each group following intraperitoneal injections was directly due to the tumorigenic action of GaAs, GaP or Ga 2 O 3 or not, it appears that these substances produce a potential systemic toxicity in mice following intraperitoneal injections.