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The synthesis of metallocene‐labelled drugs for biological assays
Author(s) -
Lavastre I,
Besançon J,
Brossier P,
Moise C
Publication year - 1990
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590040104
Subject(s) - chemistry , nortriptyline , desipramine , metallocene , organic chemistry , nuclear magnetic resonance spectroscopy , chromatography , combinatorial chemistry , stereochemistry , pharmacology , medicine , neuroscience , biology , amitriptyline , hippocampus , polymerization , antidepressant , polymer
Several drugs (amphetamine, desipramine, nortriptyline, phenobarbital) have been labelled with metallocenic fragments in order to develop a new immunoassay method. The metallocenic fragments are cymantrenic or benchrotrenic derivatives: the linkage between the organic and organometallic moieties has been achieved by reactions between amino and acidic functional groups. All the products (metallohaptens), purified by different chromatography techniques, have been fully characterized by IR and 1 H NMR spectroscopy and their mass spectra.