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Structural effects on the antitumour activity of a series of di(4‐substituted phenyl)tin dichloride complexes with nitrogen‐donor ligands
Author(s) -
Biddle Brain N,
Gray John S
Publication year - 1989
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590030610
Subject(s) - chemistry , substituent , stereochemistry , tin , ligand (biochemistry) , medicinal chemistry , electronic effect , steric effects , receptor , organic chemistry , biochemistry
Investigation of the antitumour activity of a series of diorganotin dichloride complexes (4‐ZC 6 H 4 ) 2 SnCl 2 ·L 2 , where Z = OMe, Me, F, Cl, and CF 3 and L 2 = 2,2′‐bipyridyl (bipy), 1,10‐phenanthroline (phen) and 2‐aminomethylpyridine (amp) is reported. A number of these complexex are shown to exhibit reproducible activity in vivo towards P388 lymphocytic leukaemia in mice. 1 H NMR data are reported for an extended series of (4‐ZC 6 H 4 ) 4 Sn and the parent dichlorides (4‐ZC 6 H 4 ) 2 SnCl 2 of the above‐mentioned complexes. A correlation is reported between Hammett substituent constants and 1 H chemical shift data. Attempts are made to relate the antitumour activity of the complexes to various structural factors. The dependence of antitumour activity on the electronic effect of group Z and the nature of the ligand L 2 is demonstrated.