Synthesis of the selective antimuscarinic agent 4‐{[cyclohexylhydroxy(2‐methoxyphenyl)silyl]‐methyl}‐1,1‐dimethylpiperazinium methyl sulfate ( o ‐methoxy‐sila‐hexocyclium methyl sulfate) | Zendy

Tacke Reinhold | Zendy; Rafeiner Klaus | Zendy; Strohmann Carsten | Zendy; Mutschler Ernst | Zendy; Lambrecht Günter | Zendy

Premium

Synthesis of the selective antimuscarinic agent 4‐{[cyclohexylhydroxy(2‐methoxyphenyl)silyl]‐methyl}‐1,1‐dimethylpiperazinium methyl sulfate ( o ‐methoxy‐sila‐hexocyclium methyl sulfate)

Author(s) -

Tacke Reinhold,

Rafeiner Klaus,

Strohmann Carsten,

Mutschler Ernst,

Lambrecht Günter

Publication year - 1989

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.590030203

Subject(s) - chemistry , muscarinic acetylcholine receptor , sulfate , silylation , derivative (finance) , tertiary amine , stereochemistry , amine gas treating , receptor , medicinal chemistry , organic chemistry , biochemistry , financial economics , economics , catalysis

The synthesis of the potent and highly selective silicon‐containing antimuscarinic agent o ‐methoxysila‐hexocyclium methyl sulfate and its corresponding tertiary amine (isolated as the dihydrochloride) is described. The quarternary compound is an o ‐methoxy derivative of sila‐hexocyclium methyl sulfate, which represents one of the tools currently used in experimental pharmacology for the subclassification of muscarinic receptors. The o ‐methoxy derivative, the pharmacological profile of which differs substantially from that of the nonmethoxy compound, is also recommended as a tool for the investigation of muscarinic receptor heterogeneity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research