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The metabolism of methylarsine oxide and sulfide
Author(s) -
Cullen William R,
McBride Barry C,
Manji Hasseini,
Pickett A Wendy,
Reglinski John
Publication year - 1989
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590030107
Subject(s) - chemistry , arsenite , sulfide , glutathione , veillonella , biochemistry , metabolism , oxide , arsenic , organic chemistry , bacteria , enzyme , streptococcus , biology , genetics
Methylarsine oxide and sulfide are more toxic to Candida humicola than arsenite; the sulfide is rapidly metabolized to trimethylarsine (Me 3 As) and methylarsine (MeAsH 2 ) and the oxide to dimethylarsinic acid [Me 2 AsO(OH)]. Cell‐free extracts of C. humicola also convert the oxide to Me 2 AsO(OH). The glutathione (RSH) derivative Me 2 AsSR is metabolized by C. humicola to Me 3 As and Me 2 AsH, but some other Me 2 AsSR′ compounds are unaffected. Studies involving the interaction of the arsenic(III) compounds with natural ecosystems and other micro‐organisms such as Scopulariopsis brevicaulis , Straptococcus sanguis , Escherichia coli , and Veillonella alcalescens are described.