The metabolism of methylarsine oxide and sulfide | Zendy

Cullen William R | Zendy; McBride Barry C | Zendy; Manji Hasseini | Zendy; Pickett A Wendy | Zendy; Reglinski John | Zendy

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The metabolism of methylarsine oxide and sulfide

Author(s) -

Cullen William R,

McBride Barry C,

Manji Hasseini,

Pickett A Wendy,

Reglinski John

Publication year - 1989

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.590030107

Subject(s) - chemistry , arsenite , sulfide , glutathione , veillonella , biochemistry , metabolism , oxide , arsenic , organic chemistry , bacteria , enzyme , streptococcus , biology , genetics

Methylarsine oxide and sulfide are more toxic to Candida humicola than arsenite; the sulfide is rapidly metabolized to trimethylarsine (Me 3 As) and methylarsine (MeAsH 2 ) and the oxide to dimethylarsinic acid [Me 2 AsO(OH)]. Cell‐free extracts of C. humicola also convert the oxide to Me 2 AsO(OH). The glutathione (RSH) derivative Me 2 AsSR is metabolized by C. humicola to Me 3 As and Me 2 AsH, but some other Me 2 AsSR′ compounds are unaffected. Studies involving the interaction of the arsenic(III) compounds with natural ecosystems and other micro‐organisms such as Scopulariopsis brevicaulis , Straptococcus sanguis , Escherichia coli , and Veillonella alcalescens are described.

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