Premium
Correlation of molecular total surface area with organotin toxicity for biological and physicochemical applications
Author(s) -
Eng G,
Tierney E J,
Bellama J M,
Brinckman F E
Publication year - 1988
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590020211
Subject(s) - chemistry , toxicity , daphnia magna , steric effects , stereochemistry , positive correlation , organic chemistry , medicine
There exists a high correlation between molecular total surface area (TSA) values and diorganotin toxicity towards several distinct types of organisms. This correlation was found for N 2 a neuroblastoma cells, 3T3 fibroblasts, Daphnia magna Rhithropanopeus harrisii and Ankistrodesmus falcatus . In the case of Rhithropanopeus harrisii , a high correlation was also found between TSA and toxicity for triorganotins as well. This study suggests that the relationship between TSA and toxicity is a function of the hydrophobicity of the organotin compounds rather than electronic or steric effects.