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Synthesis and psychotropic properties of furyl‐ and thienyl‐germatranes
Author(s) -
Lukevics Edmunds,
Ignatovich Lubov,
Porsiurova Natalia,
Ǧērmane Skaidrīte
Publication year - 1988
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590020205
Subject(s) - chemistry , moiety , triethanolamine , halogen , organic chemistry , stereochemistry , medicinal chemistry , analytical chemistry (journal) , alkyl
Trihalogermyl‐furans and ‐thiopheneswere prepared by inserting germanium dibromide (GeBr 2 ) generated from the dibromogermane(II) dioxanate complex into the carbon‐halogen bond of halo‐furans and ‐thiophenes. Their ethanolysis and transesterification by triethanolamine yielded the germatraneswhich were subjected to psychotropic activity assays. The psychotropic properties of germatranes were found to depend on the type of the heterocycle and on the position of the germatrane moiety.