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The selective introduction of organometallic markers into estrogens. A‐ring propargylation of β‐estradiol
Author(s) -
Greenfield S,
Gruselle M,
Jaouen G,
Varghese V,
Nicholas K M
Publication year - 1987
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590010509
Subject(s) - chemistry , ring (chemistry) , moiety , selectivity , propargyl , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
of the propargyl dicobalt hexacarbonyl moiety onto the estradiol A ring as a potential probe in receptor studies requires protection of the ring phenolic group, and the regio‐selectivity of the attack (2‐ versus 4‐position) depends on the bulkiness of the organometallic carbenium ion.

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