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The acute toxicity of tri‐n‐butyltin taurocholate
Author(s) -
Sherman Larry R,
Soma Denise M,
Thoman Charles J
Publication year - 1987
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590010410
Subject(s) - tributyltin , chemistry , toxicity , acute toxicity , gastrointestinal tract , taurocholic acid , pharmacology , biochemistry , environmental chemistry , bile acid , organic chemistry , medicine
The acute toxicity for tri‐n‐butyltin taurocholate (TBT‐TA), a newly synthesized organotin steroid, was determined using Long Evans rats. The organotin compound was suspended in corn oil and administered by gavage using standard techniques. The TBT‐TA exhibited a taurocholic acid toxicity at 24 h and a tributyltin toxicity at three days. The LD 50 values were 611 and 384 mg kg −1 respectively. The dead rats exhibited distended stomachs, enlarged cecums, and lesions in the gastrointestinal tract. The toxicity is similar to that observed with other trialkyltin compounds.