Premium
A novel magnetically separable laccase‐mediator catalyst system for the aerobic oxidation of alcohols and 2‐substituted‐2,3‐dihydroquinazolin‐4(1 H )‐ones under mild conditions
Author(s) -
Shokri Zahra,
Azimi Nahid,
Moradi Sirvan,
Rostami Amin
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5899
Subject(s) - chemistry , catalysis , laccase , oxidizing agent , dehydrogenation , hydroquinone , substrate (aquarium) , palladium , electron transfer , mesoporous material , combinatorial chemistry , heterogeneous catalysis , photochemistry , organic chemistry , enzyme , oceanography , geology
In this study, a magnetically reusable artificial metalloenzyme has been constructed by co‐immobilization of palladium nanoparticles as a strong oxidizing catalyst and laccase as an oxygen‐activating enzyme into the cavities of magnetic mesocellular foams silica (Pd‐Laccase@MMCF). The combination of Pd‐Laccase@MMCF and hydroquinone (HQ) act as electron‐transfer mediator system and make stepwise electron transfer from substrate to molecular oxygen. This catalyst system was used for the aerobic (i) oxidation of alcohols to the corresponding carbonyl compounds and (ii) dehydrogenation of 2‐substituted‐2,3‐dihydroquinazolin‐4(1 H )‐ones in phosphate buffer (0.1 M, pH 4.5, 4 mL)/THF (4%, 1 mL) as solvent under mild conditions. The co‐immobilization of both laccase and Pd onto high surface area mesoporous support, high catalytic activity and magnetically separable and reusable make the present catalyst system superior to other currently available electron‐transfer mediator systems.