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Choline chloride‐urea deep eutectic solvent as an efficient media for the synthesis of propargylamines via organocuprate intermediate
Author(s) -
Abtahi Bahareh,
Tavakol Hossein
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5895
Subject(s) - choline chloride , chemistry , deep eutectic solvent , urea , catalysis , chloride , eutectic system , solvent , coupling reaction , choline , organic chemistry , combinatorial chemistry , biochemistry , alloy
A facile method for the synthesis of various propargylamines derivatives with different structural parts has been reported. The reaction has consisted of one‐pot coupling between aldehydes, secondary amines and terminal alkynes using CuCl as a catalyst and choline chloride/urea DES as a cheap and biocompatible reaction media. The procedure is free of using toxic solvents and used CuCl as an available, inexpensive and non‐toxic catalyst. Using this methodology, 15 different propargylamine derivatives were successfully synthesized at 60 °C in 15 hr, mostly in good yields.