Premium
Synthesis, characterization, duplex‐DNA interactions, and anticancer activities of novel octahedral [Ni(phen) 2 (dppz‐idzo)] 2+ and [Co(phen) 2 (dppz‐idzo)] 3+ complexes
Author(s) -
Abulhasanov Bahrouz,
Yıldız Ufuk,
Akkoç Senem,
Coban Burak
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5866
Subject(s) - chemistry , intercalation (chemistry) , dna , octahedron , crystallography , ligand (biochemistry) , electrospray ionization , stereochemistry , nuclear chemistry , inorganic chemistry , mass spectrometry , crystal structure , biochemistry , receptor , chromatography
Two new octahedral [Ni(phen) 2 (dppz‐idzo)] 2+ and [Co(phen) 2 (dppz‐idzo)] 3+ complexes have been synthesized and characterized by CHN analysis, electrospray ionization‐MS, nuclear magnetic resonance, and UV–Vis spectra. The DNA‐binding ability of these complexes was spectrophotometrically, hydrodynamically, and electrophoretically evaluated which indicated that they strongly intercalate into the DNA double helix, and that both induced severe DNA damage in the presence of peroxide. The complexes also showed strong antiproliferative effect against HepG2 and MDA‐MB‐231 cells. By contrast, they were found to be inactive against the MCF‐7 cell line. The ligand itself was found to be inactive against the cells tested.