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Structure and characterization of organotin bimetallic supramolecular coordination polymers based on copper cyanide building blocks and pyrazine or pyrazine‐2‐carboxylic acid as new promising anticancer agents
Author(s) -
Etaiw Safaa Eldin H.,
Marie Hasan,
Elsharqawy Fatma A.
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5831
Subject(s) - pyrazine , chemistry , cyanide , supramolecular chemistry , copper , octahedral molecular geometry , octahedron , coordination polymer , tetrahedral molecular geometry , crystallography , abts , crystal structure , stereochemistry , medicinal chemistry , inorganic chemistry , organic chemistry , antioxidant , dpph
The supramolecular coordination polymers (SCP); ∞ 3 [Cu (CN) 2 (Me 3 Sn)(pyz)], pyrazine‐trimethyltin‐bis (cyanide) copper I SCP 1 , [Cu 2 (CN) 3 (Ph 3 Sn)(pyz)], pyrazine‐triphenyltin‐tris (cyanide) dicopper I SCP 3 and [Cu 2 (CN) 4 (Ph 3 Sn)(Pyz2caH) 2 ], bis‐pyrazine‐2‐carboxylic acid‐ triphenyltin‐tetrakis (cyanide) dicopper I SCP 4 and the coordination complex (CC), [Cu II (Pyz2‐ca) 2 (H 2 O) 2 ]; diaquo‐bis‐(pyrazine‐2‐carboxylato) copper (II) complex: CC 2 , are synthesized by self‐assembly method at ambient conditions. Single crystal X‐ray structures of SCP 1 and CC 2 indicate the presence of Cu I and Cu II which adopt tetrahedral and octahedron geometry, respectively. The structures of SCP 3 and SCP 4 are solved by the density functional theory (DFT) calculations and spectroscopic methods. The Cu centers acquire triagonal plane, linear and tetrahedral geometry, respectively. The CN‐R 3 Sn‐NC spacer and pyrazine or pyrazine‐2‐carboxylic acid ligands extend the structures to 3D‐network. The tested compounds 1–4 are designed and synthesized to examine their effects on viability and proliferation of five human cancer cell lines. Also, they are tested for antioxidant activity using ABTS assay and rate erythrocyte hemolysis.