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Synthesis, physico‐chemical characterization and bioevaluation of Ni(II), Pd(II), and Pt(II) complexes with 1‐( o ‐tolyl)biguanide: Antimicrobial and antitumor studies
Author(s) -
Nuţă Ileana,
Badea Mihaela,
Chifiriuc Mariana Carmen,
Bleotu Coralia,
Popa Marcela,
Daniliuc ConstantinGabriel,
Olar Rodica
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5807
Subject(s) - chemistry , monoclinic crystal system , orthorhombic crystal system , antimicrobial , biguanide , shewanella oneidensis , crystallography , ligand (biochemistry) , denticity , hydrogen bond , crystal structure , stereochemistry , molecule , bacteria , organic chemistry , biochemistry , medicine , receptor , metformin , diabetes mellitus , endocrinology , biology , genetics
New complexes of type [M(tbg) 2 ]Cl 2 [tbg = 1‐( o ‐tolyl)biguanide; M = Ni(II), Pd(II), and Pt(II)] were synthesized and characterized to develop new biologically active compounds. The features of the complexes were assigned from microanalytical and thermal data. The NMR, FT‐IR, and UV‐Vis spectra were established by comparison with HtbgCl. All complexes exhibit a square‐planar geometry resulting from the chelating behavior of tbg. The HtbgCl and [Ni(tbg) 2 ]Cl 2 complexes were fully characterized by single‐crystal X‐ray diffraction. The HtbgCl species crystallize in the monoclinic C 2/ c spatial group, while the Ni(II) complex adopts an orthorhombic Pna 2 1 spatial group. The structure is stabilized by a complex hydrogen bonds network. The in vitro antimicrobial assays revealed improved antimicrobial activity for complexes in comparison with the ligand against both planktonic and biofilm embedded microbial cells. The most efficient compound, showing the largest spectrum of antimicrobial activity, including Gram‐positive and Gram‐negative bacteria, as well as fungal strains, in both planktonic and biofilm growth states was the Pd(II) complex, followed by the Pt(II) complex. The Pt(II) compound exhibited the most significant antiproliferative activity on the human cervical cancer SiHa cell line, inducing a cell cycle arrest in the G2/M phase.