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Fe 2 O 3 @[proline]–CuMgAl–LDH: A magnetic bifunctional copper and organocatalyst system for one‐pot synthesis of quinolines and 2 H ‐indazoles in green media
Author(s) -
Esfandiary Naghmeh,
Heydari Akbar
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5760
Subject(s) - chemistry , bifunctional , reagent , catalysis , combinatorial chemistry , azide , proline , green chemistry , solvent , condensation , one pot synthesis , organic chemistry , ionic liquid , amino acid , biochemistry , physics , thermodynamics
A novel magnetic core–shell Fe 2 O 3 @[proline]–CuMgAl–L(ayered)D(ouble)H(ydroxide) was designed as an efficient bifunctional catalytic system. To this end, Cu (II) was combined with Mg and Al in the LDH structure and l ‐proline was intercalated between LDH layers in order to perform a straightforward synthesis of quinolines and 2H ‐indazoles as two important pharmaceutical N ‐aryl‐substituted heterocyclic compounds. In this regard, a facile method was employed through consecutive condensation under a mild conditions in choline azide media, which played the role of a reagent and a solvent to avoid toxic solvents and hazardous azidation reagents. These techniques provided considerable improvement in terms of using green media, reducing starting materials, reaching higher yields and offering a shorter reaction time and lower temperature. In conclusion, it was found that the catalyst could be reused five times with no significant loss of activity.