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CoFe 2 O 4 @SiO 2 ‐NH 2 ‐Co II NPs catalyzed Hantzsch reaction as an efficient, reusable catalyst for the facile, green, one‐pot synthesis of novel functionalized 1,4‐dihydropyridine derivatives
Author(s) -
Allahresani Ali,
Mohammadpour Sangani Mehri,
Nasseri Mohammad Ali
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5759
Subject(s) - chemistry , catalysis , aldehyde , ethyl acetoacetate , ammonium acetate , solvent , nanoparticle , heterogeneous catalysis , magnetic nanoparticles , reaction conditions , nuclear chemistry , inorganic chemistry , organic chemistry , chemical engineering , high performance liquid chromatography , engineering
A magnetically heterogeneous CoFe 2 O 4 @SiO 2 ‐NH 2 ‐Co II nanoparticle was synthesized by the immobilization of Co (II) complex onto CoFe 2 O 4 @SiO 2 nanoparticles, and the heterogeneous magnetic nanocatalyst was characterized by XRD, TEM, TGA, EDX, and FT‐IR techniques. Then, the green and reusable method was introduced for a multicomponent synthesis of 1,4‐dihydropyridine derivatives via Hantszch reaction. The synthesis of 1,4‐dihydropyridine derivatives was proceeded by the reaction of aldehyde, ethyl acetoacetate, and ammonium acetate in the presence of this magnetic nanocatalyst in EtOH/Water (1:1). Simple work‐up, short reaction times, excellent yields (60–96%) as well as green solvent are some advantages of this novel approach, and the corresponding products were purified with no need for chromatographic separation.