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Fe 3 O 4 @SiO 2 ‐CeCl 3 Catalyzed Chemoselective Synthesis of Functionalized 3‐Substituted‐1,5‐Benzodiazepines via One‐pot Multicomponent and Domino Reactions
Author(s) -
Zhou Laiyun,
Wang Mingliang,
Wang Kaixuan,
Wen Tiantian,
Wang Lanzhi
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5707
Subject(s) - chemistry , catalysis , domino , nucleophile , intramolecular force , reaction conditions , nucleophilic addition , combinatorial chemistry , organic chemistry
Fe 3 O 4 @SiO 2 ‐CeCl 3 catalyzed chemoselective synthesis of functionalized 3‐substituted‐1,5‐benzodiazepines via one‐pot multicomponent and domino reactions has been developed. During the one‐pot synthesis process, one new cycle and four new bonds (one C–C, two C–N and one C=C) were constructed by the nucleophilic addition and eliminate reaction (dehydration etc.) process, intramolecular proton transfer and cyclization process. The major advantages of the present method are good to excellent yields, shorter reaction time, simple experimental procedure, easy work up, mild reaction conditions, recyclability of the catalyst and ability to tolerate a variety of functional groups which gives economical as well as ecological rewards.