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A divergent procedure for multicomponent synthesis of novel ferrocenyl derivatives of dicyanoanilines and cyanopyridines
Author(s) -
Mojtahedi Mohammad M.,
Hosseinkhany Samaneh,
Abaee M. Saeed,
Mesbah A. Wahid
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5675
Subject(s) - chemistry , malononitrile , reaction conditions , precipitation , organic chemistry , component (thermodynamics) , catalysis , thermodynamics , physics , meteorology
A divergent procedure was developed for multicomponent reaction of ferrocenecarboxaldehyde with malononitrile and various cyclic ketones. Ultrasonic irradiation of 1.0:1.0:2.0 ethanolic mixtures of the reactants produced dicyanoanilines 4 chemoselectively in high yields, while equimolar mixtures of the same reactants in refluxing EtOH solely resulted in four‐component formation of cyanopyridines 5 . Both series of products are obtained directly by spontaneous precipitation in the reaction mixtures avoiding cumbersome and expensive chromatographic separations.