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Synthesis, characterization, CT‐DNA binding and docking studies of novel selenated ligands and their palladium complexes
Author(s) -
Prabhu Kumar K.M.,
Vasantha Kumar B.C.,
Kumar P. Raghavendra,
Butcher Ray J.,
Vivek H.K.,
Suchetan P.A.,
Revanasiddappa H.D.,
Foro Sabine
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5634
Subject(s) - chemistry , palladium , schiff base , binding constant , crystallography , chelation , stereochemistry , titration , dna , binding site , inorganic chemistry , organic chemistry , catalysis , biochemistry
A novel selenated Schiff base ( S ) ‐L 1 H has been synthesized from (2 S )‐1‐(benzylselanyl)‐3‐phenylpropan‐2‐amine which upon reduction formed a reduced Schiff base ( S ) ‐L 2 H . Palladium (II) complexes ( S ) ‐1 and ( S ) ‐2 of ligands ( S ) ‐L 1 H and ( S ) ‐L 2 H respectively were successfully synthesized. The structures of all four compounds were thoroughly identified by analytical and various spectroscopic techniques. The absolute molecular structures of the above two complexes were further confirmed by single crystal X‐ray diffraction. Both ( S ) ‐L 1 H and ( S ) ‐L 2 H coordinated as monobasic (( S ) ‐L 1–2 ), chelating, tridentate (Se,N,O − ) ligands resulting in the complexes of composition ( S ) ‐ [PdCl( L 1/2 )] [( S ) ‐1/2 ]. In the crystals of complexes ( S ) ‐1 and ( S ) ‐2 , there were moderate to strong Se⋯O, CH⋯Cl and CH⋯O types of intermolecular secondary interactions. CT‐DNA binding activity of these selenium‐containing ligands and their palladium complexes bearing a Pd–Se bond have been evaluated for the first time by performing electronic absorption titration and fluorescence emission quenching using CT‐DNA‐EB and viscometric experiments. These ligands and complexes exhibited remarkable DNA binding activity as shown by their intrinsic DNA binding constants ( K b ) and Stern–Volmer constants ( K sv ) in the ranges 5.2–9.9 × 10 4 and 3.6–4.7 × 10 4 , respectively. The viscosity of CT‐DNA decreases with increasing concentration of these compounds. The results of the DNA‐binding studies revealed that all of the compounds interact with DNA at a minor groove which was further confirmed by molecular docking studies.

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