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89 Zr Labeled Fe 3 O 4 @TiO 2 Nanoparticles: In Vitro Afffinities with Breast and Prostate Cancer Cells
Author(s) -
Unak Perihan,
Tekin Volkan,
Guldu Ozge Kozgus,
Aras Omer
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5616
Subject(s) - photodynamic therapy , nanoparticle , chemistry , dynamic light scattering , magnetic nanoparticles , transmission electron microscopy , nanotechnology , nuclear magnetic resonance , materials science , organic chemistry , physics
In this study, Fe 3 O 4 @TiO 2 nanoparticles were synthesized as a new Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) hybrid imaging agent and radiolabeled with 89 Zr. In addition, Fe 3 O 4 nanoparticles were synthesized and radiolabeled with 89 Zr. Df‐Bz‐NCS was used as bifunctional ligand. The nanoconjugates were characterized with transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. Radiolabeling yields were 100%. Breast and prostate cancer cell affinities and cytotoxicity were determined using in vitro cell culture assays. The results demonstrated that Fe 3 O 4 @TiO 2 nanoparticles are promising for PET/MR imaging. Finally, unlike Fe 3 O 4 nanoparticles, Fe 3 O 4 @TiO 2 nanoparticles showed a fluorescence spectrum at an excitation wavelength of 250 nm and an emission wavelength of 314 nm. Therefore, in addition to bearing the magnetic properties of Fe 3 O 4 nanoparticles, Fe 3 O 4 @TiO 2 nanoparticles display fluorescence emission. This provides them with photodynamic therapy potential. Therefore multimodal treatment was performed with the combination of PDT and RT by using human prostate cancer cell line (PC3). The development of 89 Zr‐Df‐Bz‐NCS‐Fe 3 O 4 @TiO 2 nanoparticles as a new multifunctional PET/MRI agent with photodynamic therapy and hyperthermia therapeutic ability would be very useful.