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A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations
Author(s) -
Naveen P.,
Vijaya Pandiyan B.,
Anu D.,
Dallemer F.,
Kolandaivel P.,
Prabhakaran R.
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5605
Subject(s) - chemistry , octahedral molecular geometry , ethylamine , ligand (biochemistry) , ethidium bromide , acridine orange , nuclear chemistry , crystallography , dna , organic chemistry , crystal structure , apoptosis , biochemistry , receptor
A new mixed nickel–sodium complex has been synthesized from Ni(ClO 4 ) 2 and tris(8‐methyl 2‐oxo‐quinolidine amino ethylamine) with a 1:1 molar ratio in methanol and has been characterized by various analytical, spectroscopy and X‐ray diffraction studies which confirmed an octahedral geometry around the nickel ion. Further, structural optimization of the complex was performed using DFT calculations. The ligand and complex were evaluated for their binding affinity with CT‐DNA and an intercalative type of binding interaction was proposed from the absorption and fluorescence titration experiments. Albumin binding interaction of the ligand and complex was determined by absorption, fluorescence and synchronous spectral techniques at room temperature, suggesting the static quenching mechanism of BSA with the compounds. Antioxidant studies revealed the radical scavenging potential of Ni(II) complex. The anticancer activity of the ligand and complex was probed via in vitro cytotoxicity against human breast (MCF7) and lung (A549) cancer cell lines by MTT assay. Further, cytological changes observed in acridine orange/ethidium bromide and DAPI staining methods validated the cytotoxic potential of the complex.