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Anchoring of Cu (II)‐Schiff base complex on magnetic mesoporous silica nanoparticles: catalytic efficacy in one‐pot synthesis of 5‐substituted‐1H‐tetrazoles, antibacterial activity evaluation and immobilization of α‐amylase
Author(s) -
Ahmadi Ameneh,
Sedaghat Tahereh,
Motamedi Hossein,
Azadi Roya
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5572
Subject(s) - chemistry , schiff base , nuclear chemistry , catalysis , magnetic nanoparticles , mesoporous material , antibacterial activity , nanoparticle , nanocomposite , mesoporous silica , tetrazole , polymer chemistry , organic chemistry , nanotechnology , materials science , bacteria , biology , genetics
Abstract Magnetic mesoporous silica nanocomposite, Fe 3 O 4 @MCM‐41, was prepared and functionalized with N‐(2‐aminoethyl)‐3‐aminopropyltrimethoxysilane (AEAPS). Then Schiff base grafted nanoparticles were synthesized by the condensation of 5,5'‐methylene bis (salicylaldehyde) and then benzhydrazide with Fe 3 O 4 @MCM‐41‐AEAPS. Finally, by adding Cu (CH 3 COOH) 2 .H 2 O, the magnetic nanoparticles (MNPs) functionalized with Cu (II) Schiff base complex were synthesized. The new organic–inorganic hybrid nanocomposite was characterized by FT‐IR, PXRD, AAS, BET, TGA, VSM, FE‐SEM, HRTEM and EDX techniques. Then, the performance of this copper based magnetic nanocatalyst was investigated for the synthesis of 5‐substituted 1 H ‐tetrazole derivatives using one pot three‐component reactions of various aldehydes, hydroxyl amine hydrochloride and sodium azide. The catalyst can be easily isolated from the reaction mixture by applying an external magnet and reused for at least 5 times without significant loss in catalytic activity. Also, the antibacterial activity of the streptomycin loaded magnetic nanoparticles against Gram‐positive ( S. aureus ) and Gram‐negative ( E. coli ) bacteria in the presence and absence of a magnetic field were studied. Results revealed that when these materials exposed to the magnetic field, bacteriostatic activity of nanocomposites was increased. Furthermore, the enzyme immobilization ability of the synthesized compounds was investigated and the results showed that these nanoparticles efficiently immobilized amylase enzyme.