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Characterization of bis‐Schiff bases synthesized using ZnFe 2 O 4 nanoparticles as catalyst, and examination of their antibacterial and in vitro cytotoxic properties
Author(s) -
Maaref Hamed,
Sheikhhosseini Enayatollah,
Foroughi Mohammad Mehdi,
Akhgar Mohammad Reza,
Jahani Shohreh
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5557
Subject(s) - chemistry , catalysis , schiff base , nuclear chemistry , nanoparticle , antimicrobial , antibacterial activity , infrared spectroscopy , condensation reaction , aqueous solution , organic chemistry , polymer chemistry , nanotechnology , bacteria , materials science , biology , genetics
In this study, ZnFe 2 O 4 nanoparticles (NPs) were prepared by a hydro/solvothermal method, and their structures were characterized by infrared, scanning electron microscopy, energy‐dispersive X‐ray spectroscopy and X‐ray diffraction analyses. These ZnFe 2 O 4 NPs were used in the synthesis of new bis‐Schiff bases by condensation of hydroxyl‐substituted aldehydes with various aromatic diamines in aqueous media. The antimicrobial activities of the synthesized bis‐Schiff bases were tested against gram‐negative as well as gram‐positive bacteria. The MTT method was used to assess the anticancer activity of the bis‐Schiff bases towards human lung and breast cancer cell lines. The results indicated that these compounds could be considered as new anti‐tumor candidates.