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Retracted : A new class of copper(I) complexes with imine‐containing chelators which show potent anticancer activity
Author(s) -
Choodari Milani Neda,
Maghsoud Yazdan,
Hosseini Mahdieh,
Babaei Abouzar,
Rahmani Hamidreza,
Roe Stephen Mark,
Gholivand Khodayar
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5526
Subject(s) - chemistry , hydrogen bond , imine , supramolecular chemistry , pyridine , crystal structure , crystallography , ligand (biochemistry) , intermolecular force , stereochemistry , metal , proton nmr , copper , molecule , medicinal chemistry , organic chemistry , receptor , biochemistry , catalysis
Seven novel complexes (C 1 –C 7 ) were synthesized by the interaction between Cu(I) metal cation, L 1 , L 2 , L 3 , X and PPh 3 , where L 1 –L 3 are derivatives of ((pyridine‐2‐ylmethylene)amino)phenol imine ligands and X = Cl − , Br − , I − , NCS − . All the complexes were characterized using infrared, 1 H NMR and 31 P NMR spectroscopies. The crystal structures of C 1 –C 7 were also determined using single‐crystal X‐ray diffraction. The organization of the crystal structures and the intermolecular interactions are discussed. The supramolecular assemblies are driven by cooperative π…π interactions and hydrogen bonds, followed by CH…π linkages. The potential anticancer effect of C 1 –C 7 was assessed for human glioblastoma cells using several anticancer experiments, which showed that these complexes have marked anticancer property against U87 cells. It was also found that the minimum and maximum anticancer effects are shown by C 3 ‐ and C 4 ‐treated samples, respectively. Furthermore, theoretical approaches were used to investigate the nature of metal–ligand interactions which suggest a closed‐shell and electrostatic character for Cu…N, Cu…P and Cu…X bonds.