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Palladium‐catalyzed cyclization reaction of N‐(2‐Haloaryl)alkynylimines: Synthesis of 3‐acylindoles using water as the sole solvent and oxygen source
Author(s) -
Zhang AnAn,
Meng Tuanjie,
Wang Wenli,
Liu Xueli,
Zhu Yupei,
Liu Lantao
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5513
Subject(s) - chemistry , catalysis , palladium , solvent , combinatorial chemistry , oxygen , organic chemistry
A simple and efficient strategy for the preparation of 3‐acylindoles via palladium‐catalyzed cyclization reaction of N ‐(2‐haloaryl)alkynylimines in water has been developed. The reaction tolerates a wide range of functional groups, and the corresponding 3‐acylindoles were obtained in high yields using water as the sole solvent and oxygen sources. Additionally, this method could provide a short synthesis route for Pravadoline, a phase II analgesic drug.