Palladium‐catalyzed cyclization reaction of N‐(2‐Haloaryl)alkynylimines: Synthesis of 3‐acylindoles using water as the sole solvent and oxygen source | Zendy

Zhang AnAn | Zendy; Meng Tuanjie | Zendy; Wang Wenli | Zendy; Liu Xueli | Zendy; Zhu Yupei | Zendy; Liu Lantao | Zendy

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Palladium‐catalyzed cyclization reaction of N‐(2‐Haloaryl)alkynylimines: Synthesis of 3‐acylindoles using water as the sole solvent and oxygen source

Author(s) -

Zhang AnAn,

Meng Tuanjie,

Wang Wenli,

Liu Xueli,

Zhu Yupei,

Liu Lantao

Publication year - 2020

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.5513

Subject(s) - chemistry , catalysis , palladium , solvent , combinatorial chemistry , oxygen , organic chemistry

A simple and efficient strategy for the preparation of 3‐acylindoles via palladium‐catalyzed cyclization reaction of N ‐(2‐haloaryl)alkynylimines in water has been developed. The reaction tolerates a wide range of functional groups, and the corresponding 3‐acylindoles were obtained in high yields using water as the sole solvent and oxygen sources. Additionally, this method could provide a short synthesis route for Pravadoline, a phase II analgesic drug.

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